The pleiotropic benefits of statins
Webbis important to evaluate the overall benefit of statins in an older population. To this end, our disability-free survival outcome including detailed ascertainment of dementia using well validated measures of cognition, such as those used in the ASPREE trial 35 and advocated by others, 33 will allow us to determine whether statins reduce major ... WebbSeveral aspects of the endocrine system have been shown to be influenced by the pleiotropic effects that statins exert, however, the benefits of statins on cardiovascular morbidity and mortality largely outweigh this deleterious effect, and statin therapy should continue to be recommended. BACKGROUND The 3-Hydroxy-3-MethylGlutaryl-CoA …
The pleiotropic benefits of statins
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WebbIndeed, recent studies indicate that some of the cholesterol-independent or “pleiotropic” effects of statins involve improving endothelial function, enhancing the stability of … WebbAlong with lipid-lowering potency, the beneficial pleiotropic effects of statins, such as the antibacterial and immunomodulatory properties, may act in a dose-dependent fashion. …
WebbMost pleiotropic effects of statins in cell cultures can be reversed by the addition of mevalonate. Effects that are mediated by Rho GTPases are attributed to the isoprenoid, geranylgeranlpyrophosphate (GGPP). Therefore, increasing mevalonate or GGPP concentrations within extra hepatic cells could limit the benefits of statins. WebbStatins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide (NO) bioavailability. AMP-activated protein kinase (AMPK) plays a central role in controlling energy and metabolism homeostasis in various organs. We therefore studied whether statins can activate AMPK, and if so, whether the activated ...
WebbEvidence for the pleiotropic effects of statins in heart failure comes largely from retrospective and subgroup analyses of large studies. When statin therapy is compared … Webb13 feb. 2024 · Indeed, several randomized controlled trials showed the benefits of statins both in the primary and secondary prevention of cardiovascular disease, which appear to be primarily due to LDL cholesterol (LDL-C) reduction but also to antiinflammatory, antithrombotic, antioxidant, and plaque-stabilizing effects [5,6,7,8,9,10,11,12].
Webb30 apr. 2024 · This misconception, and therefore reluctance to prescribe statins, may indirectly deny patients with chronic liver disease significant clinical benefit (Fig. 1).Unrelated to its lipid-lowering effects, statins have a wide array of pleiotropic effects, ranging from antioxidant, antifibrotic, anti-inflammatory, and improvement of endothelial …
Webb8 apr. 2024 · The greatest improvements were recorded in the fluvastatin and dual therapy groups, suggesting the statin had played a dominant role. 28 Remarkably, a significant increase in nitric oxide and reduction in endothelin-1 was observed in the two groups receiving statins, indicating that the pleiotropic effects of this drug are fundamental for … shut light off on iphoneWebbThis paper builds on these findings and presents practical guidance for maximising the pleiotropic benefits of this class of medicines in people with T2DM in terms of reducing adverse CVD outcomes. The Improving Diabetes Steering Committee aims to offer evidence-based practical guidance for the use of SGLT2i therapies in people with T2DM … the paddocks extra care housing oxfordshireWebb15 maj 2024 · Statins also impart a modest benefit in concentrations of triglycerides, high-density lipoproteins (HDL) and very low-density lipoproteins (VLDL). 2 Moreover, statins exert pleiotropic effects such as improvement of endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and … shut light offWebb1 aug. 2024 · Clinical benefits, such as reduction of recurrent ischemic events, have been documented in a recent prospective study after short-term treatment with statins. 134 Mechanistic explanations of the benefits are derived not only from the actions of statin on atherogenic lipoproteins (VLDL, IDL, and LDL) but equally on inflammation, endothelial … shutline manga chapter 25WebbSaeid Ghavami Associate Editor at Elsevier, Frontiers, PLOS, and MDPI publishing group shut laptop screen when using external screenWebb12 feb. 2016 · Statin agents have been established as standard therapy for acute coronary syndrome (ACS) patients. The beneficial effects attribute to the pleiotropic actions of statin agents, of which low-density lipoprotein cholesterol (LDL-C) lowering effects are the most important. 10 But for ACS patients with low LDL-C level, statin therapy can benefit … the paddocks hytheWebb25 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis. Nat. Cardiovasc. Res. 1, … shut lights off sign