WebA syngeneic mouse model was established through the subcutaneous transplantation of a tumor tissue fragment from a TH-MYCN transgenic mouse, and the homing effects of anti-GD2-MSCs were validated ... WebMar 31, 2015 · Hyperplasia in TH-MYCN mice is mainly composed of undifferentiated progenitor cells . To confirm that the Phox2B + neuronal progenitors were in an undifferentiated state, the tissue sections were immunostained for markers of mature sympathetic neurons. Fig. 3 demonstrates the morphology of mature sympathetic …

Indisulam targets RNA splicing and metabolism to serve as a

WebJul 10, 2012 · Th-MYCN hemizygous mice were bred with Th-ALK F1174L hemizygous mice, and litters were genotyped to detect the presence of human MYCN or ALK F1174L transgenes. After weaning, at about day 28, animals hemizygous for both transgenes or MYCN alone were palpated for intra-abdominal tumors twice weekly. WebMar 15, 2014 · A genetically well-explored autologous mouse model for NBL is the TH-MYCN model. However, the immunobiology of the TH-MYCN model remains largely … irc sec 415 h

Molecular imaging of neuroblastoma progression in TH-MYCN …

WebAug 16, 2004 · TH-MYCN mice developed large, paravertebral thoracic or abdominal tumors at a median of 6.5 (±0.27) weeks in 100% of homozygotes and by 13 (±2.67) weeks in 33% of hemizygotes . These tumors were indistinguishable from human neuroblastoma tissue based on histologic, immunohistochemical, and cytogenetic studies . To better ... WebJun 10, 2024 · Methods TH-MYCN mice were treated with 14G2a (anti-GD2 antibody), isotype antibody, or phosphate buffered saline from day 14 of life until day 100 or signs of morbidity. Survival was recorded, and tumors were isolated in terminal surgeries for analysis of GD2 expression and immune cell frequencies. Tumors from untreated mice were … WebOct 7, 2024 · TH-MYCN transgenic mice over-express MYC-N under the control of the tyrosine hydroxylase promoter and spontaneously develop aggressive tumors, closely … irc sec 311b