Phospho sting
WebNational Center for Biotechnology Information WebSTING (TMEM173), also called stimulator of interferon genes, is a transmembrane adaptor protein that plays an important role in the innate immune response against viral and bacterial infections. It has been shown that cyclic GMP-AMP synthase (cGAS) plays a key role in STING activation.
Phospho sting
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WebPhospho-STING (Ser365) Antibody (PA5-117271) in WB Western blot analysis of extracts of THP-1 cells using Phospho-STING (Ser365) Polyclonal Antibody (Product # PA5-117271). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Product Details WebSTING activation in patient tumors and in platinum-treated preclinical NSCLC models was correlated with biomarkers of immunotherapy response. Results: STING activation is associated with higher levels of intrinsic DNA damage, targetable immune checkpoints, and chemokines in treatment-naive and relapsed lung adenocarcinoma.
WebInterestingly, we found that STING interacts with both TBK1 and IRF3, and that mutations in STING that selectively disrupt its binding to IRF3 abrogate IRF3 phosphorylation without impairing TBK1 activation. ... IRF3 also bound to phospho-TBK1 [TRAF family member-associated NFκB activator (TANK)-binding kinase] (Fig. 4 E and G), which is a ... WebPhospho-STING-S365 Rabbit pAb (AP1199) Publication (1) Datasheet SDS Tested applications: WB Reactivity: Human, Mouse Western blot analysis of extracts of THP-1 cells, using Phospho-STING-S365 antibody (AP1199) at 1:1000 dilution.THP-1 cells were treated by PMA (80 nM) at 37℃ for overnight.
WebA common control for phospho-specific antibodies involves treating your lysates with calf intestinal phosphatase or lambda protein phosphatase. If the antibody is phospho-specific, the signal will disappear after phosphatase treatment (Figure 1). WebPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser366 of human STING protein. Antibodies are purified by protein A and peptide affinity chromatography. Validations. None provided. Applications. Immunoprecipitation (IP) Western Blotting (WB) Reactivity. Homo sapiens …
Web产品说明. The Human Monocyte STING Activation Flow Cytometry Panel includes antibodies targeting phospho-STING (Ser366) and phenotyping markers to enable observation of STING activation in human monocyte populations among peripheral blood mononuclear cells (PBMCs). CD45 is a pan leukocyte marker. Monocytes and dendritic cells (DCs) are ...
WebMar 25, 2024 · Stimulator of interferon genes (STING) contributes to immune responses against tumors and may control viral infection including SARS-CoV-2 infection. theory a vs theory b cbtWebSep 19, 2013 · This paper provides previously undescribed evidence that STING, an endoplasmic reticulum (ER)-resident protein involved in DNA sensing, couples ER stress … theory a vs theory b worksheetWeb55. A method of treating, inhibiting, reducing, ameliorating, and/or preventing a cancer and or metastasis in a subject comprising administering to a subject an adoptive immunothe shrub auctionWebThe confocal microscopic analysis of phospho-STING along with NeuN in CX shows that 3 days after TBI expression of phospho-STING is increased in the neurons compared to sham. Treatment of GSK2656157 after TBI decreased phospho … shrub around houseWebJun 7, 2024 · The assay showed the dependency of STING phosphorylation on the STING agonist, TBK1, “ER-to-Golgi” traffic, and palmitoylation, which mirrored the nature of … theory back pocket pantsWebPhospho-STING (Ser366) Antibody recognizes endogenous levels of STING protein only when phosphorylated at Ser366. Species Reactivity: Human Source / Purification … shrubb breeding timeWebCell Signaling Technology Inc rabbit monoclonal anti human phospho sting ser366 d8k6h Rabbit Monoclonal Anti Human Phospho Sting Ser366 D8k6h, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more shrub background